Once lined with abandoned warehouses on the wrong side of the Main River, Hanauer Landstrasse, in Frankfurt's industrial East End, is enjoying a second act as one of the city's new social epicenters.

1. Sansibar

In warm months, lounge on bamboo chairs, sip champagne, and admire the city views from this open-air roof bar and lounge. No. 190; 49-69/9139-6147; sansibar.us; open Wednesdays-Saturdays; drinks for two $22.

2. King Kamehameha

Pioneering nightclub King Ka (as regulars call it) was first on the block and is still going strong— it's even spawned an outpost on Majorca. No. 192; 49-69/480-0370; king-kamehameha.de.

3. Das Leben Ist Schön

The walls of this trattoria are lined with vintage photographs of Italian families; the wooden tables are packed with fans of the paper-thin pizzas and the "Abbondanza!" vibe. No. 198; 49-69/4305-7870; dinner for two $41.

4. Galerie Adler

Adler's focus is strictly contemporary, with exhibitions of local and international talent working in all media, from video to plastic. No. 134; 49-69/4305-3962; galerieadler.com.

5. Goldman 25hours Hotel

Germany's media and art luminaries favor this 49-room hotel's color-saturated, mischievous design (the lamps are penguins wearing shades on their heads) and its boisterous bar scene. No. 127; 49-69/4058-6890; 25hours-hotels.com; doubles from $124.