Barrydale—100 miles east of Cape Town—is becoming a South African Santa Fe, with galleries, wineries, boutique hotels, and hiking trails, set amid the Western Cape's vast Klein Karoo. Below, an easy itinerary.

Dook A bird's eye view of the lush Tradouw Valley.
| Credit: Dook

DESTINATION Barrydale, South Africa GO FROM Cape Town TRAVEL TIME 2 1/2 hours by car GETTING THERE Take Route 62, the fabled road through the Klein Karoo valley, east from Cape Town. The Mediterranean climate and rolling vineyards will remind you of southern Spain STAY 1 or 2 nights

DAY ONE Make your home base at Denis McLintock and Leon Riley's Tradouw Guesthouse (46 van Riebeeck St.; 27-28/572-1434;; doubles from $65). This former 19th-century general store with a vine-covered courtyard opened in 1997, luring the first weekenders from Cape Town. Start at a slow pace over coffee and a piece of toast with house-made fruit preserves at the Jam Tarts (Rte. 62, Barrydale; 27-28/572-1173; breakfast for two $15), a café and gallery. Continue the art tour by checking out local contemporary work at the Mud Gallery (Rte. 62, Barrydale; 27-28/572-1950). For dinner, drop into Bistro Blues (15 Laing St.; 27-28/572-1232; dinner for two $30); natives swear by the small joint's juicy steak and other comfort food. Don't let the evening end without heading out to Ronnies Sex Shop (Km. 26, Rte. 62; 27-28/572-1153; After farmer Ronnie Price's friends prankishly inserted the word sex into his former farm stand's signage, so many motorists stopped by that Price converted the spot into a down-home pub. It may well be the weirdest bar in the Western Cape.

DAY TWO Book a room at the historic Barrydale Hotel (30 van Riebeeck St.; 27-28/572-1226;; doubles from $37). The property, which dates back to the 1880's, received a kitschy makeover (complete with fox-fur lounge chairs and oil paintings of drag queens) in 2000 by new owners Riaan Bosch and Philip Uys. To sample the region's best Cabernets and Merlots, drive seven miles west to Tradouw Valley's vineyards—family-owned Joubert-Tradauw Private Cellars (Vleiplaas; 27-28/572-1619; Then have your designated driver take the winding Tradouw Pass through the majestic Langeberg Mountains; in 10 miles you'll bump right into the Indian Ocean. Top off a day of decadence with a sophisticated local lamb curry at Clarke of the Karoo (Main Rd., Barrydale; 27-28/572-1017; dinner for two $35).

SIDE TRIP Prefer a luxe safari setting?Spend a night at the new Sanbona Wildlife Reserve (Rte. 62; 27-28/572-1365;; doubles from $420) on the outskirts of town. It has the only free-roaming pride of white lions in the world.

Clarke of the Karoo

Bistro Blues

Jam Tarts

Sanbona Wildlife Reserve

Cape 62 is a 200-mile scenic drive that starts in Cape Town and heads west to Little Karoo; it also serves as the entry to the 134,000-acre Sanbona Wildlife Reserve, in South Africa’s lush Breede River Valley. The reserve is home to three lodging experiences: The nine Dwyka-tented lodges are set in a dry river bend, near ancient San rock art; Gondwana Lodge is made up of 12 contemporary suites with floor-to-ceiling windows onto the Anysberg Mountains; and a more traditional Cape Georgian design scheme is on display in the six suites of the 1898 Tilney Manor. Authentic Karoo cuisine—such as smoked venison—are included in the rate, as are two game drives a day, for spotting the Big Five, plus springbot, ostrich, and riverine rabbit.

Barrydale Hotel

Tradouw Guesthouse