Named for the Italian Renaissance architect and engineer Filippo Brunelleschi, this historic property in the heart of Florence occupies the Byzantine Pagliazza Tower. (Fans of Dan Brown may recognize it as Robert Langon's hotel of choice in The DaVinci Code and Inferno.) The 96 guestrooms range from deluxe doubles to the 1,237-square-foot penthouse apartment. Rooms have a modern aesthetic, with parquet floors, marble bathrooms, four-posted beds, and velvet headboards (in bright solid colors such as purple and red). At the on-site, seven-table restaurant Santa Elisabetta, exposed stone walls and wood-beamed ceilings set the stage for Florentine cuisine. The Tower Lounge Bar is the place for afternoon tea, a midday snack, and pre- or post-dinner cocktails.