On-trend touches like hanging Egg chairs and pendant fixtures add a youthful edge to this 102-year-old high-rise on Michigan Avenue. But the biggest draw is the dead-on views of Millennium Park in a number of the 218 guest rooms. hoteljulianchicago.com; doubles from $220.
Sophy Hyde Park
This artsy bolt-hole is the first luxury hotel in Hyde Park, one of the city’s foremost cultural hubs—and the future home of the Obama Presidential Center. The 98 guest rooms draw upon the vibrant energy of the neighborhood, with abstract paintings by Chicago artist Joey Korom and record players with a hand-picked selection of vinyl. sophyhotel.com; doubles from $289.
Housed inside the beloved Carbide & Carbon building, this chic newcomer harks back to the dawn of the skyscraper, with an original Art Deco façade and interior details like crystal chandeliers and herringbone tile floors. At the street-level restaurant, Free Rein, chef Aaron Lirette whips up American brasserie favorites like roast chicken with garlic jus. stjanehotel.com; doubles from $269.
The digerati will embrace the various tech-centric amenities (robot butlers, in-room Amazon Alexas) at this art- and science-themed hotel, whose lobby contains a seven-foot zoetrope machine. But the vibe is never gimmicky, thanks to design-forward interiors outfitted with dark parquet floors, tufted leather furniture, and copper accents. hotelemc2.com; doubles