By Jaime Gillin
October 23, 2012

Take a vibrant mix of Victorians and historic warehouses. Fill them with inventive boutiques and restaurants. Add an industrial waterfront district—and you’ve got San Francisco’s newest creative epicenter.

Yellow Building

The area’s beating heart is an 1890’s stable that now houses Piccino ($$)—a convivial restaurant dedicated to thin-crust pizzas and small plates—as well as an outpost of Modern Appealing Clothing, known for avant-garde fashions, and Dig, a wine shop and bar. Minnesota and 22nd Sts.

Workshop Residence

Head here for goods crafted by hand on-site, including silk crepe dresses from Paris-based designer Aurore Thibout and wood-and-leather wedges from local artisan Martha Davis. 833 22nd St.

Chocolate Lab

Cult brand Recchiuti Confections’ long-awaited café serves rich desserts such as mandarin-chocolate-mousse cake and lime-meringue tartlets. A few doors down is Little Nib, their new retail shop. 801 22nd St.

Mr. & Mrs. Miscellaneous

With its tattooed owners, gleaming steel fixtures, and far-out flavors (black sesame; candied violet), this isn’t your grandpa’s ice cream parlor. Almost everything is house-made, from the waffle cones to the peanut brittle cookies. 699 22nd St.; 415/970-0750.

Museum of Craft & Design

This cultural hub has a slick new home in a former can-manufacturing plant. Triple the space means more room to showcase special exhibitions such as whimsical metal-and-wood sculptures by Bay Area artist Michael Cooper. 2569 Third St.