Neighborhood: Arty, of-the-moment Karaköy, a once-downtrodden harbor district now revitalized with cafés and galleries.
Style: Low-luster bling with a touch of the traditional. Architect Sinan Kafadar gave this 1875 Neoclassical building a modern makeover, styling the interiors in neutral tones and stocking the 71 rooms with Malin & Goetz toiletries.
Don’t Miss: The top-floor bar, where the city’s in-crowd comes to party. Doubles from $220; pictured above.
Courtesy of St. Regis
Neighborhood: Leafy, Parisian-feeling Nişantaşi, a tony enclave of high-end residences and luxury boutiques.
Style: Art Deco meets beigy-tastefulness. Local designer Emre Arolat outfitted the 118 plush rooms in this newly built structure with dark wood and velvet-lined armchairs.
Don’t Miss: Contemporary Turkish sculptures and paintings on loan from the family-run Demsa Group, the city’s top private art collection. Doubles from $525.
Courtesy of Soho House
Neighborhood: Youthful Beyoğlu, known for its Art Nouveau buildings, raki bars, and shopping thoroughfare.
Style: Clubby, boutique-hotel cool. The group refashioned a 19th-century palazzo in its typical masculine aesthetic and restored the original Italianate details (frescoes, stainedglass windows).
Don’t Miss: The Embassy—it’s surprisingly the brand’s first-ever nightclub. Doubles from $221.
Courtesy of Raffles
Neighborhood: Levent, an affluent, business-oriented riverside district. The hotel is part of the Zorlu Center, home to upscale shops.
Style: Sexy Ottoman opulence. Chandeliers adorn the lobby, while the 181 rooms feature mosaic-tiled bathrooms, prints inspired by the Blue Mosque, and sweeping Bosporus views.
Don’t Miss: The knockout 33,000-square-foot spa, which has three hammams and two pools. Doubles from $681.