Driving from Pullman, in southeastern Washington.
With its seemingly endless grass-covered silt dunes, the Palouse is gorgeous in spring. There are 11 communities along the 208-mile byway, but the college town of Pullman is the best base for exploring. From there, you can walk amongst grizzlies (at a safe distance, of course), gaze down at gushing waterfalls, and hike scenic trails, flanked by rolling hills and farmland.
Palouse Falls State Park
Take a photo op where the falls plunge into a perfectly round canyon.
The creative pizzas (Polish sausage and sauerkraut is a favorite) make it a great pit stop.