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4000 Rua Elídio Gonçalves da Silva, São Paulo, 12460-000, Brazil

High in the mountains of Vale dos Mellos, 160 miles northwest of São Paulo, sits a stone-and-glass lodge conceived to showcase the best of the country. There’s the wine cellar (all Brazilian); the food (farm-to-fork); and the furnishings (sourced by Adélia Borges, the country’s leading design authority). The six suites and 11 villas are built with reclaimed wood and have terraces that overlook the valley. But this is not luxury to satisfy all tastes—floorboards are rough, bathrooms doorless, and décor is on the spare side. Still, the range of activities—horseback riding, capoeira, cooking classes—are enough to keep the most restless of guests happy.

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Botanique Hotel and Spa

High in the mountains of Vale dos Mellos, 160 miles northwest of São Paulo, sits a stone-and-glass lodge conceived to showcase the best of the country. There’s the wine cellar (all Brazilian); the food (farm-to-fork); and the furnishings (sourced by Adélia Borges, the country’s leading design authority). The six suites and 11 villas are built with reclaimed wood and have terraces that overlook the valley. But this is not luxury to satisfy all tastes—floorboards are rough, bathrooms doorless, and décor is on the spare side. Still, the range of activities—horseback riding, capoeira, cooking classes—are enough to keep the most restless of guests happy.