Museo de Arte de Puerto Rico

Housed in a Neoclassical former hospital in San Juan's Santurce neighborhood, this 130,000-square-foot space became the Caribbean's most extensive art museum when it opened in 2000. The 1,100-piece collection includes prominent Puerto Rican artists from the 17th century to the present day. There's also a five-acre sculpture garden, the perfect place for a quiet interlude before having lunch at the swank on-site restaurant, Pikayo.