This trendsetting refuge for downtown movers and shakers still has as much élan as it did when it opened in 1996. Interior designer William Sofield has channeled the neighborhood's 19th-century industrial look with exposed lightbulbs, wire grids, and a well-trafficked glass-bottle staircase that's flanked by steel Great Danes. Designer jeans are de rigueur in the second-floor Grand Bar & Lounge, a corridor with a polished gold marble bar and a selection of 50 rare American whiskys. The 353 rooms feature platform beds with brown-leather headboards and black-and-white photography, with whimsical counterweights such as wry cartoon-bird illustrated wallpaper, and a custom copper penny desk. The two $5,500-a-night penthouse suites are the epitome of chic urban living.