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52 Santa Isabel, Madrid, 28012, Spain | +34 91 774 1000

Set in a massive 18th-century hospital building dramatically expanded by architect Jean Nouvel a decade ago, Spain’s official modern and contemporary art museum can seem like a daylong undertaking. But visitors should feel comfortable dipping into the galleries that appeal to them and breezing past others. Just don't overlook the works by 20th-century masters Salvador Dalí, Juan Gris, Joan Miró, and of course Pablo Picasso, whose mural-sized Guernica, depicting the horrors of aerial bombing in the Spanish Civil War, ranks among the most iconic—and moving—images of the 20th century.

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Museo Reina Sofia

Set in a massive 18th-century hospital building dramatically expanded by architect Jean Nouvel a decade ago, Spain’s official modern and contemporary art museum can seem like a daylong undertaking. But visitors should feel comfortable dipping into the galleries that appeal to them and breezing past others. Just don't overlook the works by 20th-century masters Salvador Dalí, Juan Gris, Joan Miró, and of course Pablo Picasso, whose mural-sized Guernica, depicting the horrors of aerial bombing in the Spanish Civil War, ranks among the most iconic—and moving—images of the 20th century.