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700 W. Main St., Louisville, KY 40202, United States
The art-focused 21c Museum Hotel Louisville is a clear standout in Kentucky. New York architect Deborah Berke renovated five 19th-century brick buildings, transforming them into an industrial chic hotel with exposed brick walls. The impressive collection of rotating paintings, sculptures, videos, and installations makes a stay here a must for art lovers. It scored 90.222 on T+L’s World’s Best Awards and one reader even said, “I would live here if I could.”
© 21c Museum Hotels

Louisville’s 21c ranks as a bona fide cultural institution in the making, not just a hotel with art. Designed by New York architect Deborah Berke—and owned by husband-and-wife preservationists Steve Wilson and Laura Lee Brown—the 91-room property showcases an impressive, rotating collection of paintings, sculptures, photos, and video installations by living artists (hence the hotel’s name, a reference to the 21st century). Occupying five 19th-century brick buildings, 21c showcases Berke’s spare-but-polished industrial style, with exposed-brick walls.

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21c Museum Hotel Louisville

Louisville’s 21c ranks as a bona fide cultural institution in the making, not just a hotel with art. Designed by New York architect Deborah Berke—and owned by husband-and-wife preservationists Steve Wilson and Laura Lee Brown—the 91-room property showcases an impressive, rotating collection of paintings, sculptures, photos, and video installations by living artists (hence the hotel’s name, a reference to the 21st century). Occupying five 19th-century brick buildings, 21c showcases Berke’s spare-but-polished industrial style, with exposed-brick walls.