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136 Calle Pallacio, Cuzco, , Peru

In the Andean capital of Cuzco, this 16th-century former Jesuit seminary—a relic of Spanish colonial architecture with two landscaped courtyards and covered arcades—has been transformed by Orient-Express Hotels. The 126 guest rooms, no longer the ascetic monks’s cells of yore, are individually furnished with antique-style furniture and modern technology; many ward off altitude sickness with pumped-in oxygen-enriched air. The Baroque chapel houses religious artwork, including an impressive collection of Cuzquenian School paintings dating from the 17th century. After a long day hiking Cuzco's cobblestone hills, guests can unwind in the barrel-vaulted Lobby Bar before dining at Peruvian restaurant Deli Monasterio.

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Belmond Hotel Monasterio

In the Andean capital of Cuzco, this 16th-century former Jesuit seminary—a relic of Spanish colonial architecture with two landscaped courtyards and covered arcades—has been transformed by Orient-Express Hotels. The 126 guest rooms, no longer the ascetic monks’s cells of yore, are individually furnished with antique-style furniture and modern technology; many ward off altitude sickness with pumped-in oxygen-enriched air. The Baroque chapel houses religious artwork, including an impressive collection of Cuzquenian School paintings dating from the 17th century. After a long day hiking Cuzco's cobblestone hills, guests can unwind in the barrel-vaulted Lobby Bar before dining at Peruvian restaurant Deli Monasterio.