21c Museum Hotel, Cincinnati
Like the 21c Museum Hotels did with Louisville, Cincy’s historic urban core has been revitalized. A neglected, 100-year-old downtown building has been transformed into a chic hotel and contemporary art space with rotating exhibitions. Ever true to its mission, the brand’s founders, Laura Lee Brown and Steve Wilson, preserved many of the original details—mosaic tile floors, large-scale arched windows—and filled each of the 156 modern rooms with original works. You’ll know you’ve arrived when you see 21c’s iconic penguins in the city’s signature yellow hue.