Over-the-Rhine (OTR)—known for its Italianate architecture—has gone from historic to hip.
Inventive Japanese gastropub and sushi bar Kaze amps up its ramen with littleneck clams and red miso broth; turkey sliders are piled high with sugar bacon, shiitake mushrooms, and house-made pickles. 1400 Vine St. $$$
The founders of 21c Museum Hotel set their sights on a landmark building for their second art-filled property. Technically just outside of OTR, it displays works in unexpected places; take the lobby floor, where a panel of wormlike neon patterns changes as you walk on it. Make sure to grab a drink on the rooftop terrace. 609 Walnut St. $$