Tsala Treetop Lodge

Why It’s Unique: Overlooking the Tsitsikamma Forest, the architecturally stunning stone-and-glass lodge has 10 secluded treehouse suites, each with floor-to-ceiling bedroom windows, log fireplace in the living room, private deck, and infinity-edge pool.

Access: Wooden walkways.

What to Do: During the day, explore South Africa’s Garden Route, which winds along the botanically rich Western Cape, or relax on the beaches at nearby Plettenberg Bay.