St. Regis Grand Hotel

This opulent 19th-century landmark palace opened by César Ritz and designed by architect Giulio Podesti, a 10-minute walk from the Via Veneto, made the most of its $35 million restoration in 2007. Guests step into a luxurious haven, with hand-painted frescoes forming dramatic backdrops to tufted guest-room headboards, 24-hour “e-butler” service, and chandeliers made from handblown Murano glass. The 161 ravishing rooms feature décor from the Italo-Franco Louis XVI, Regency, and Empire periods and furniture evocative of the Mediterranean’s regal lineage from all eras; expect rich velvets, inlaid woods, carved marble, and fine Pratesi linens. Bathrooms come with travertine marble and Laura Tonatto toiletries, while the on-site health club (accessed via the hotel’s original wrought-iron elevator) is state of the art. If dining in, book a table in the cozy wine cellar of the hotel’s award-winning restaurant, Vivendo.