DAY 1 From Telluride, head west to Placerville on Highway 145, northeast on Highway 62, then south on Highway 550 to Ouray. Order the spinach enchiladas at Buen Tiempo Restaurant & Cantina (426 Main St., Ouray; 970/325-4951 or 866/243-1502), and get an Aveda massage at the Wiesbaden Hot Springs Spa & Lodgings (625 Fifth Ave., Ouray; 970/325-4347 or 888/846-5191; www.wiesbadenhotsprings.com; $89, including access to swimming pool and vapor cave). Stay at the Box Canyon Lodge & Hot Springs (45 Third Ave., Ouray; 800/327-5080 or 970/325-4981; www.boxcanyonouray.com; doubles from $100).
DAY 2 Take the Million Dollar Highway (Highway 550) south to Silverton, and follow Route 110 east to Animas Forks. Backtrack through Silverton, heading south to Durango. Sleep at the Lightner Creek Inn (999 County Rd. 207, Durango; 800/268-9804 or 970/259-1226; www.lightnercreekinn.com; doubles from $95, including breakfast).
DAY 3 Drive southeast from Durango on Highway 172 (511 in New Mexico) for a swim in Navajo Lake (505/632-2278 for information). Take Highway 64 west to Shiprock, and Highway 666 north (160 in Colorado) to Cortez. Follow Highway 145 to Dolores, and stay at the Rio Grande Southern Hotel (101 S. Fifth St., Dolores; 800/258-0434 or 970/882-7527; www.riograndesouthernhotel.com; doubles from $75, including breakfast).
DAY 4 Head back to Telluride via Highway 145.