Top among the city’s many new downtown properties is the 24-suite Anandá Hotel Boutique (doubles from $395), a quiet retreat in a restored Spanish-colonial building with carved-wood balconies and three breezy roof terraces.
At Restaurante DonJuan (dinner for two $100), chef Juan Felipe Camacho—who apprenticed at Spain’s Michelin-starred Arzak—dishes up Spanish-inflected Caribbean fare (think grilled shrimp with pico de gallo).
Related: T+L’s Definitive Guide to Cartagena
Housed in a 17th-century monastery, El Coro bar (cocktails for two $24), at Hotel Sofitel Santa Clara, lures locals and guests alike with pitch-perfect mojitos and the prospect of glimpsing writer and occasional barfly Gabriel García Márquez.
Bill Gates and Spanish King Juan Carlos I are devotees of Ego, the pint-size workshop where tailor Edgar Gómez Estévez has been creating his white linen guayabera shirts for 35 years.