Steve Kepple

Known for its vibrant Latino culture, colorful murals, and hip, artistic spirit, the Mission is now experiencing a second coming with a new crop of restaurants, boutiques, and more.

Stay

Set in an 1872 mansion, the 21-room Inn San Francisco (doubles from $175) brims with authentic Victorian details—ornate woodwork; marble fireplaces; featherbeds—minus the chintz (not a weathered doily in sight). Don’t miss the rooftop deck with 360-degree views of the city.

Eat

The izakaya Nombe (dinner for two $50)—its name translates, roughly, to “drunkard”—serves haute Japanese pub food (grilled shishito peppers with bottarga; grilled skewers of chicken thigh with ume and shiso) accompanied by a great sake list. Added bonus: the kitchen is open until 2 a.m. on Fridays and Saturdays, an anomaly in the city. Chef-owner Matt Straus turns out simple, yet delicious, seasonal dishes at the intimate Heirloom Café (dinner for two $80). But for a real treat, ask for the off-menu burger with Époisses cheese.

Shop

Siblings Danielle and Luke Teller helm the well-edited Afterlife Boutique, which carries reconstructed antique jewelry by the shop’s Adoura Demode line and collectible rock-concert T-shirts priced from $45 to $1,000.

The light-filled Gravel & Gold is a treasure hunter’s dream, filled with everything from Japanese paper goods to wool blankets made on Prince Edward Island.

Do

A showcase for local, cutting-edge artists, Southern Exposure relocated last fall to a soaring 4,000-square-foot gallery.

Inn San Francisco

Set in an 1872 mansion, the 21-room property brims with authentic Victorian details—ornate woodwork; marble fireplaces; featherbeds—minus the chintz (not a weathered doily in sight). Don’t miss the rooftop deck with 360-degree views of the city.

Nombe

The izakaya Nombe—its name translates, roughly, to “drunkard”—serves haute Japanese pub food (grilled shishito peppers with bottarga; grilled skewers of chicken thigh with ume and shiso) accompanied by a great sake list. Added bonus: the kitchen is open until 2 a.m. on Fridays and Saturdays, an anomaly in the city.

Heirloom Café

Chef-owner Matt Straus turns out simple, yet delicious, seasonal dishes at this intimate restaurant. But for a real treat, ask for the off-menu burger with Époisses cheese.

Afterlife Boutique

Siblings Danielle and Luke Teller helm the well-edited Afterlife Boutique, which carries reconstructed antique jewelry by the shop's Adoura Demode line and collectible rock-concert T-shirts priced from $45 to $1,000.

Gravel & Gold

The light-filled store is a treasure hunter's dream, filled with everything from Japanese paper goods to wool blankets made on Prince Edward Island.

Southern Exposure

This showcase for local, cutting-edge artists relocated in fall 2009 to a soaring 4,000-square-foot gallery.

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