America's Greatest Main Streets
Andre Jenny / Alamy
Located above the Tombigbee River in northeastern Mississippi, Columbus is perhaps most famous for being the birthplace of Tennessee Williams. The Victorian house where the playwright grew up reopened as the town’s official welcome center in 1993 after being relocated to Main Street among small shops and restaurants that serve classic southern cooking. An increasing number of locals have chosen to move into apartments above such businesses, adding to the buzz of this downtown.
Worth a Stop: Located just off Main Street, the Hitching Lot Farmers’ Market runs from April to October with special Saturday events including live music plus watermelon-seed-spitting and corn-shucking contests during summer months.