America's Best Spring Drives

Kenneth Hayden

Ohio River Scenic Byway, Cincinnati to Louisville

The Route: 99 miles.

Crossing three states, the Ohio River Scenic Byway stretches nearly a thousand miles. Follow the river downstream from Cincinnati to Louisville, where you can check out Derby City’s Old Louisville SpringFest, a daylong street festival that will have a “Parisian Flea Market” and gourmet food vendors—not to mention a bourbon tent!

Where to Stop: Louisville’s hottest hotel is the 90-room 21c Museum Hotel, which has a $10 million collection of artwork, photos, and video installations, plus the popular Proof on Main restaurant. Look for another 21c opening in Cincinnati in late 2012.

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Travel + Leisure

America's Best Spring Drives

Ohio River Scenic Byway, Cincinnati to Louisville

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