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America's Best Road Trips

America's Best Road Trips: Ohio River Scenic Byway, Cincinnati to Louisville

Kenneth Hayden

Ohio River Scenic Byway, Cincinnati to Louisville

Crossing three states, the Ohio River Scenic Byway stretches nearly a thousand miles. Follow the river downstream from Cincinnati to Louisville, and stay at the city’s hottest hotel, the 90-room 21c Museum Hotel, which has a $10 million collection of artwork, photos, and video installations.

Where to Stop: For a slight detour from the byway, pick up a map for Kentucky’s Bourbon Trail at the Louisville Visitors Center and head out to taste more than 50 bourbons from nearby distilleries such as Jim Beam, Woodford Reserve and Maker’s Mark. The trail stops at 21c’s Proof on Main restaurant and bar.

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